| CAS
NO. |
378-44-9
(Base)
5593-20-4 (Dipropionate) |
|
| EINECS
NO. |
206-825-4,
227-005-2 |
| FORMULA |
C28H37FO7 |
| MOL
WT. |
504.60 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
Betamethasone 17,21-dipropionate;
|
| 9-Fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione
17,21-dipropionate; Pregna-1,4-diene-3,20-dione,
9-fluoro-11-hydroxy-16-methyl- 17,21-bis (1-oxopropoxy)-, (11beta,16beta)-;
|
|
DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
White
crystalline powder |
| MELTING
POINT |
Decomposes |
| BOILING
POINT |
|
| SPECIFIC
GRAVITY |
|
| SOLUBILITY
IN WATER |
|
| pH |
|
| VAPOR
DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
Health:
2 Flammability: 0 Reactivity: 0 |
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
Betamethasone, a synthetic glucocorticoid, an analog of prednisolone derived
from cortisol, having activity in replacement therapy for adrenal insufficiency
and as an antiinflammatory and immunosuppressant. Betamethasone has the most
powerful activity of corticosteroids with a slight mineralocorticoid activity.
It is used to treat many conditions including dermatitis, arthritis,
inflammatory bowel disease, reactive airways disease, and respiratory distress
syndrome in preterm infants and pruritus in corticosteroid-responsive
dermatoses. The chemical designation is
9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione. Some
esters and salts of betamethasone for intramuscular, intraarticular,
intrasynovial, or intralesional injection include:
- Betamethasone acetate
(CAS RN: 987-24-6): The acetate ester of betamethasone; white to off-white crystalline
powder; for intramuscular, intraarticular, intrasynovial, or intralesional
injection typically in combination with betnesol.
- Betnesol (Betamethasone
disodium phosphate, CAS RN: 151-73-5): The disodium salt of the 21-phosphate
ester of betamethasone; very hygroscopic white to off-white powder; for
intramuscular, intraarticular, intrasynovial, or intralesional injection in
combination with betamethasone acetate.
- Betamethasone-17-valerate
(CAS RN: 2152-44-5); The 17-valerate ester of betamethasone, for the use of topical
inflammation relief and for dermatologic.
- Betamethasone-21-valerate
(CAS RN: 2240-28-0); The 21-valerate ester of betamethasone, for the use of topical
inflammation relief and for dermatologic.
- Betamethasone 17,21-divalerate
(CAS RN: 38196-44-0): The 17,21-Divalerate ester of betamethasone, used topically for the
relief of inflammation and pruritus in corticosteroid-responsive
dermatoses.
- Betamethasone butyrate propionate (CAS RN: 5534-02-1)
- Betamethasone
acibutate (CAS RN: 5534-05-4)
- Betamethasone-21-butyrate
(CAS RN: 56933-60-9)
- Betamethasone-21-propionate (CAS RN: 75883-07-7)
- Betamethasone
17,21-dipropionate (CAS RN: 5593-20-4)
- Betamethasone benzoate
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white
to off-white crystalline powder |
|
IDENTIFICATION
|
Complies
|
|
ASSAY
|
97.0
- 103.0%
|
|
OPTICAL
ROTATION
|
+63°
~ +70°
|
|
RELATED
SUBSTANCE
|
1.0%
max (Betamethasone 17 monpropionate)
1.0%
max (Betamethasone 21 monpropionate)
2.0% max
(Total impurity)
|
|
SOLVENT
RESIDUE
|
0.1%
max
|
|
LOSS
ON DRYING
|
1.0%
max
|
|
RESIDUE
ON IGNITION
|
0.2%
max
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD
CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
| European
Hazard Symbols: XN, Risk Phrases: 40,
Safety
Phrases: 22-36 |
| GENERAL
DESCRIPTION OF CORTICOSTEROID
|
Corticosteroid is a
synthetic or naturally occurring 21-carbon steroid
structure substances with four fused rings and vary functional branches attached to the ring
system. Cholesterol and steroid hormones have this carbon skeleton. The term steroid
refers to these three groups that contain a hydrogenated
cyclopentano perhydro phenanthrene ring system. In restricted context for medical
usage by non-endocrinologists, it refers to corticosteroids. Natural corticosteroids are elaborated by the adrenal
cortex in response to physiological carbohydrate metabolism. According to their
predominant biologic activity, they are divided into two major groups:
glucocorticoid and mineralocorticoid. Glucocorticoid's chief function is to
regulate carbohydrate, lipid, and protein metabolism and inhibit the release of
ACTH (adrenocorticotropic hormone). Glucocorticoids also affect muscle tone and
the microcirculation, participate in the maintenance of arterial blood pressure,
increase gastric secretion, alter connective tissue response to injury, impede
cartilage production, inhibit inflammatory, allergic, and immunologic responses,
invoke shrinkage of lymphatic tissue, reduce the number of circulating
lymphocytes, and affect the functions of the central nervous system. In humans,
the most important ones are cortisol, cortisone, and corticosterone.
Mineralocorticoids, uniuqely aldosterone in human, regulate the balance of water
and promote retention of sodium, loss of potassium. Aldosterone plays a role also
in promoting tissue repair. Spironolactone is the aldosterone antagonist called
potassium-sparing diuretic used in the treatment of hypertension.
Corticosteroids are used in clinically for hormonal replacement therapy, for
suppression of ACTH, as antineoplastic, antiallergic, and anti-inflammatory
agents, and to suppress immune responses.
- Glucocorticoid
Receptor Agonists
- Dexamethasone
- Triamcinolone
- Hydrocortisone
- Prednisone
- Glucocorticoid
Receptor Antagonists
- Mineralocorticoid
Receptor Agonists
- Mineralocorticoid
Receptor Antagonists
- Spironolactone
- Eplerenone
|
| PRICE
INFORMATION |
|
